Formaldehyde, Styrene - carcinogens

From Thinkprogress.org:

After David Koch Leaves NIH Board, NIH Hands Down Long-Delayed Classification Of Top Koch Pollutant As A Carcinogen

Large manufacturers and chemical producers have lobbied ferociously to stop the National Institutes of Health from classifying formaldehyde as a carcinogen. A wide body of research has linked the chemical to cancer, but industrial polluters have stymied regulators from action.

Last year, the New Yorker’s Jane Mayer reported that billionaire David Koch, whose company Georgia Pacfic (a subsidiary of Koch Industries) is one of the country’s top producers of formaldehyde, was appointed to the NIH cancer board at a time when the NIH delayed action on the chemical. The news was met with protests from environmental groups. Faced with mounting pressure from Greenpeace and the scientific community, Koch left offered an early resignation from the board in October.

Yesterday, the NIH finally handed down a report officially classifying formaldehyde as a carcinogen:

Government scientists listed formaldehyde as a carcinogen, and said it is found in worrisome quantities in plywood, particle board, mortuaries and hair salons. They also said that styrene, which is used in boats, bathtubs and in disposable foam plastic cups and plates, may cause cancer but is generally found in such low levels in consumer products that risks are low. Frequent and intense exposures in manufacturing plants are far more worrisome than the intermittent contact that most consumers have, but government scientists said that consumers should still avoid contact with formaldehyde and styrene along with six other chemicals that were added Friday to the government’s official Report on Carcinogens. Its release was delayed for years because of intense lobbying from the chemical industry, which disputed its findings.

An investigation by ProPublica found that Sens. David Vitter (R-LA) and James Inhofe (R-OK) had used their power to add years of delay to the report. The piece linked Vitter to lobbying from Koch’s Georgia Pacific company, which has plywood plants in Louisiana.

"New Alarm Bells About Chemicals and Cancer"

By N.D.Kristof in the New York Times:

The President’s Cancer Panel is the Mount Everest of the medical mainstream, so it is astonishing to learn that it is poised to join ranks with the organic food movement and declare: chemicals threaten our bodies.

The cancer panel is releasing a landmark 200-page report on Thursday, warning that our lackadaisical approach to regulation may have far-reaching consequences for our health.

I’ve read an advance copy of the report, and it’s an extraordinary document. It calls on America to rethink the way we confront cancer, including much more rigorous regulation of chemicals.

Traditionally, we reduce cancer risks through regular doctor visits, self-examinations and screenings such as mammograms. The President’s Cancer Panel suggests other eye-opening steps as well, such as giving preference to organic food, checking radon levels in the home and microwaving food in glass containers rather than plastic.

In particular, the report warns about exposures to chemicals during pregnancy, when risk of damage seems to be greatest. Noting that 300 contaminants have been detected in umbilical cord blood of newborn babies, the study warns that: “to a disturbing extent, babies are born ‘pre-polluted.’ ”

It’s striking that this report emerges not from the fringe but from the mission control of mainstream scientific and medical thinking, the President’s Cancer Panel. Established in 1971, this is a group of three distinguished experts who review America’s cancer program and report directly to the president.

One of the seats is now vacant, but the panel members who joined in this report are Dr. LaSalle Leffall Jr., an oncologist and professor of surgery at Howard University, and Dr. Margaret Kripke, an immunologist at the M.D. Anderson Cancer Center in Houston. Both were originally appointed to the panel by former President George W. Bush.

“We wanted to let people know that we’re concerned, and that they should be concerned,” Professor Leffall told me.

The report blames weak laws, lax enforcement and fragmented authority, as well as the existing regulatory presumption that chemicals are safe unless strong evidence emerges to the contrary.

“Only a few hundred of the more than 80,000 chemicals in use in the United States have been tested for safety,” the report says. It adds: “Many known or suspected carcinogens are completely unregulated.”

Industry may howl. The food industry has already been fighting legislation in the Senate backed by Dianne Feinstein of California that would ban bisphenol-A, commonly found in plastics and better known as BPA, from food and beverage containers.

Studies of BPA have raised alarm bells for decades, and the evidence is still complex and open to debate. That’s life: In the real world, regulatory decisions usually must be made with ambiguous and conflicting data. The panel’s point is that we should be prudent in such situations, rather than recklessly approving chemicals of uncertain effect.

The President’s Cancer Panel report will give a boost to Senator Feinstein’s efforts. It may also help the prospects of the Safe Chemicals Act, backed by Senator Frank Lautenberg and several colleagues, to improve the safety of chemicals on the market.

Some 41 percent of Americans will be diagnosed with cancer at some point in their lives, and they include Democrats and Republicans alike. Protecting ourselves and our children from toxins should be an effort that both parties can get behind — if enough members of Congress are willing to put the public interest ahead of corporate interests.

One reason for concern is that some cancers are becoming more common, particularly in children. We don’t know why that is, but the proliferation of chemicals in water, foods, air and household products is widely suspected as a factor. I’m hoping the President’s Cancer Panel report will shine a stronger spotlight on environmental causes of health problems — not only cancer, but perhaps also diabetes, obesity and autism.

This is not to say that chemicals are evil, and in many cases the evidence against a particular substance is balanced by other studies that are exonerating. To help people manage the uncertainty prudently, the report has a section of recommendations for individuals:

¶Particularly when pregnant and when children are small, choose foods, toys and garden products with fewer endocrine disruptors or other toxins. (Information about products is at www.cosmeticsdatabase.com or www.healthystuff.org.)

¶For those whose jobs may expose them to chemicals, remove shoes when entering the house and wash work clothes separately from the rest of the laundry.

¶Filter drinking water.

¶Store water in glass or stainless steel containers, or in plastics that don’t contain BPA or phthalates (chemicals used to soften plastics). Microwave food in ceramic or glass containers.

¶Give preference to food grown without pesticides, chemical fertilizers and growth hormones. Avoid meats that are cooked well-done.

¶Check radon levels in your home. Radon is a natural source of radiation linked to cancer.

Cancer in the Wild

From Newsweek:


In 1999, wildlife disease specialist Thierry Work looked over the bow of his small whaler as it cut through a lagoon on the south side of Molokai, an island in Hawaii. On an emergent rock he saw a listless sea turtle, waiting to die.

"This guy was so weak that he just let us pick him up," says Work, who runs the National Wildlife Health Center’sHonolulu field station. "He was so emaciated that his ventral was completely disked in. You could fill him up with water and use him as a bowl." Like more than quarter of the green turtles Work has plucked from the water or found stranded on Hawaii's beaches, this one was covered with tumors on its eyes and mouth, dying from a poorly understood form of cancer.

Work's turtle is one of a wide array of species afflicted by a range of cancers, according to a paper published in the July edition of Nature Reviews Cancer. "Wildlife Cancer: a conservation perspective," summarizes mounting evidence of human's contribution to carcinogenesis in wild-animal populations across the globe, thanks to man-made toxins dumped into wildlife's natural habitats.

"I am concerned that we as humans continue to impact the environment quite significantly," says Denise McAloose, the report's lead author and chief pathologist for the Wildlife Conservations Society's (WCS) Global Health Program. "As the human population continues to grow and utilize resources and damage the environment, I do believe that we will continue to see the emergence of disease, including cancer in wildlife."

On San Francisco's touristy Pier 39, the incessant barking of male sea lions and their harems of smaller females fills the air. Periodically Frances Gulland, the director of veterinary science at the Marine Mammal Center in neighboring Sausalito, receives calls from the pier reporting a sea lion crippled by tumors. Despite huge swelling on and around their hind flippers and anus, Gulland says the animals "mask their pain" in a last ditch effort to elude opportunistic predators. "You see that they have been struggling and struggling."

According to Gulland, 17 percent of the sea lions brought to the center die of renal failure or paralysis, caused when tumors linked to Otarine herpesvirus-1 travel up the genital tact and push against the kidney and spine. According to the Nature Reviews Cancer article, sea lions that died of genital carcinoma had an 85 percent higher concentration of toxic polychlorinated biphenyls (PCBs) in their system than other sea lions. (PCBs are toxic compounds used in coolants and electrical transformers.) Gulland points out that blubber samples of sea lions who died of cancer also show high concentrations of the pesticide dichlorodiphenyltrichloroethane (DDT), in part because many are born near the Channel Islands where 1,700 tons of the toxin were dumped prior to its ban in 1972.

In the icy waters of Canada's St. Lawrence Estuary, where researchers have been studying the local population of Beluga whales for decades, the connection between contamination and cancer is stark. The Saguenay River, which flows into the St. Lawrence Estuary, is lined with the smoking stacks of aluminum smelters, heavy producers of polycyclic aromatic hydrocarbons (PAHs). PAHs are toxic compounds formed by the incomplete burning of anything carbon based, and are long-proven carcinogens in both man and beast. Not surprisingly, the humans working the smelters along the river have shown high rates of lung cancer, while those in the vicinity who drank from taps supplied with surface water developed stomach and intestinal cancer.

Out in the estuary, researchers note a similar trend among the dead Belugas found beached or drifting out to sea. Research published in a 2002 edition of Environmental Health Perspectives found that the second leading cause of death (in 18 percent of the Beluga carcasses) was cancer, largely of the gut. That fits with the animal's feeding patterns. Belugas run their wide mouths along the sandy estuary floor, eating invertebrates like the blue mussel. The concentration of the PAH benzo[a]pyrene was 200 times higher in blue mussels in the Sanguenay River portion of the Beluga habitat than in adjacent areas.

The Belugas of Quebec are considered an endangered species, brought down by environmental pollution. The devils of Tasmania are similarly at risk, but for much different reasons.

A contagious cancer and the Tasmanian devil's penchant for fighting may be the species' death knell. In the 1990s the devil population was estimated at 150,000; by 1996 the population had been halved. The killer: devil facial tumor disease (DFTD), which affects 65 percent of the remaining population and has an unflinching mortality rate of 100 percent..

The good news for animals suffering from pollution-induced cancer is that when contaminants are taken out of the environment, some species have shown marked drops in carcinogenesis. For example, catfish living in Ohio's Black River had cancer rates ranging from 22 percent to 39 percent in the early 1980s. The disease killed virtually all fish before they reached five years of age. After a steel plant's coking facility closed in 1983, PAH levels dropped significantly; cancer rates dropped 75 percent and the amount of fish living past five years has tripled....

"Reservoirs Closed After Carcinogen Is Found"

LOS ANGELES — Two reservoirs that supply drinking water to parts of the city have been shut down and will be drained after a rare sunlight and chlorine reaction tainted the water with a cancer-causing chemical, utility officials said Friday.

The Los Angeles Department of Water and Power plans to drain 600 million gallons from the reservoirs, the Elysian and the Silver Lake, early next year, said a water department spokesman, Joseph Ramallo. The reservoirs will be out of use for three to four months amid drought conditions.

High levels of the carcinogen bromate were found in early October by a commercial customer who ran a laboratory test, officials said. The utility confirmed the finding, immediately removed the reservoirs from service and notified the Department of Public Health.

Officials emphasized that the chemical is dangerous only after long-term consumption.

The two reservoirs supply the water for about one-third of 1 percent of the city’s annual consumption, or about the amount the entire city consumes in a day, Mr. Ramallo said.

Some water from the reservoirs may be used for irrigation or firefighting, but none will be used for human consumption. The rest will be dumped into the Los Angeles River, which drains into the Pacific Ocean.